Human CD83 protein (Recombinant) (C-His) (STJP001083)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CD83 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Thr20-Ala143) of human CD83 (Accession #NP_004224.1) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human CD83-C-His protein was developed in hek293 cells using the region Thr20-Ala143. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | CD83 |
| Gene ID | 9308 |
| Uniprot ID | CD83_HUMAN |
| Immunogen | Recombinant Human CD83 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Thr20-Ala143) of human CD83 (Accession #NP_004224.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Thr20-Ala143 |
| Immunogen Sequence | TPEVKVACSEDVDLPCTAPW DPQVPYTVSWVKLLEGGEER METPQEDHLRGQHYHQKGQN GSFDAPNERPYSLKIRNTTS CNSGTYRCTLQDPDGQRNLS GKVILRVTGCPAQRKEETFK KYRA |
Additional Info
| Tissue Specificity | Expressed by activated lymphocytes, Langerhans cells and activatd dendritic cells. |
| Post Translational Modifications | Glycosylated when expressed on activated dendritic cells. |
| Function | Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation. In addition, acts as an important modulator of protective responses against acute infections. |
| Protein Name | Cd83 AntigenHcd83B-Cell Activation ProteinCell Surface Protein Hb15Cd Antigen Cd83 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Cd83 Antigen proteinHcd83 proteinB-Cell Activation Protein proteinCell Surface Protein Hb15 proteinCd Antigen Cd83 proteinCD83 protein |
Information sourced from Uniprot.org