| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human CD66b (CEACAM8)-protein was developed from hek293. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
0.2 Mu m filtered PBS solution, pH7.2. |
| Storage Instruction: |
Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: |
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Immunoreactivity: |
The activity was tested by immobilized recombinant CD66a (10ug/ml) ability to bind recombinant human CD66b in functional ELISA. NA |
| Gene Symbol: |
CEACAM8 |
| Gene ID: |
1088 |
| Uniprot ID: |
CEAM8_HUMAN |
| Immunogen Region: |
ECD |
| Immunogen: |
Optimized DNA sequence encoding extracellular domain of human CD66bincluding a C-terminal 6His tag was expressed in HEK293 cells. NA |
| Tissue Specificity | Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow. |
| Post Translational Modifications | Glycosylated. |
| Function | Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Heterophilic interaction with CEACAM8 occurs in activated neutrophils. |
| Protein Name | Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8Cd67 AntigenCarcinoembryonic Antigen Cgm6Non-Specific Cross-Reacting Antigen Nca-95Cd Antigen Cd66b |
| Database Links | Reactome: R-HSA-1566977Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorCell Surface |
| Alternative Protein Names | Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8 proteinCd67 Antigen proteinCarcinoembryonic Antigen Cgm6 proteinNon-Specific Cross-Reacting Antigen Nca-95 proteinCd Antigen Cd66b proteinCEACAM8 proteinCGM6 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
