Human CD49e/ITGA5 protein (Recombinant) (N-GST) (STJP003859)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD49e/ITGA5-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ITGA5 |
| Gene ID | 3678 |
| Uniprot ID | ITA5_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu895-Ala1049 |
Additional Info
| Post Translational Modifications | Proteolytic cleavage by PCSK5 mediates activation of the precursor. |
| Function | Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling. (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
| Protein Name | Integrin Alpha-5Cd49 Antigen-Like Family Member EFibronectin Receptor Subunit AlphaIntegrin Alpha-FVla-5Cd Antigen Cd49e Cleaved Into - Integrin Alpha-5 Heavy Chain - Integrin Alpha-5 Light Chain |
| Database Links | Reactome: R-HSA-1566948Reactome: R-HSA-1566977Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-445144Reactome: R-HSA-8941332Reactome: R-HSA-9634597Reactome: R-HSA-9856532Reactome: R-HSA-9860927 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionFocal Adhesion |
| Alternative Protein Names | Integrin Alpha-5 proteinCd49 Antigen-Like Family Member E proteinFibronectin Receptor Subunit Alpha proteinIntegrin Alpha-F proteinVla-5 proteinCd Antigen Cd49e Cleaved Into - Integrin Alpha-5 Heavy Chain - Integrin Alpha-5 Light Chain proteinITGA5 proteinFNRA protein |
Information sourced from Uniprot.org