| Post Translational Modifications | Proteolytic cleavage by PCSK5 mediates activation of the precursor. |
| Function | Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling. (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
| Protein Name | Integrin Alpha-5Cd49 Antigen-Like Family Member EFibronectin Receptor Subunit AlphaIntegrin Alpha-FVla-5Cd Antigen Cd49e Cleaved Into - Integrin Alpha-5 Heavy Chain - Integrin Alpha-5 Light Chain |
| Database Links | Reactome: R-HSA-1566948Reactome: R-HSA-1566977Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-445144Reactome: R-HSA-8941332Reactome: R-HSA-9634597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionFocal Adhesion |
| Alternative Protein Names | Integrin Alpha-5 proteinCd49 Antigen-Like Family Member E proteinFibronectin Receptor Subunit Alpha proteinIntegrin Alpha-F proteinVla-5 proteinCd Antigen Cd49e Cleaved Into - Integrin Alpha-5 Heavy Chain - Integrin Alpha-5 Light Chain proteinITGA5 proteinFNRA protein |
Information sourced from Uniprot.org
