Human CD30 (TNFRSF8) protein (Recombinant) (STJP000503)

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STJP000503

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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CD30 (TNFRSF8)-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Immunoreactivity: The activity was tested by the ability of immobilized recombinant human CD30 to bind Human CD30 Ligand with a linear range of 6-800 ng/ml NA
Gene Symbol: TNFRSF8
Gene ID: 943
Uniprot ID: TNR8_HUMAN
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding extracellular domain of Human CD30 including a C-terminal His tag was expressed in HEK293 cells. NA
Tissue Specificity Isoform 2: Detected in alveolar macrophages (at protein level).
Post Translational Modifications Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated.
Function Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 8
Cd30l Receptor
Ki-1 Antigen
Lymphocyte Activation Antigen Cd30
Cd Antigen Cd30
Database Links Reactome: R-HSA-5669034
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Cytoplasm
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 8 protein
Cd30l Receptor protein
Ki-1 Antigen protein
Lymphocyte Activation Antigen Cd30 protein
Cd Antigen Cd30 protein
TNFRSF8 protein
CD30 protein
D1S166E protein

Information sourced from Uniprot.org

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