| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human CD30 (TNFRSF8)-protein was developed from hek293. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction: | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Immunoreactivity: | The activity was tested by the ability of immobilized recombinant human CD30 to bind Human CD30 Ligand with a linear range of 6-800 ng/ml NA |
| Gene Symbol: | TNFRSF8 |
| Gene ID: | 943 |
| Uniprot ID: | TNR8_HUMAN |
| Immunogen Region: | ECD |
| Immunogen: | Optimized DNA sequence encoding extracellular domain of Human CD30 including a C-terminal His tag was expressed in HEK293 cells. NA |
| Tissue Specificity | Isoform 2: Detected in alveolar macrophages (at protein level). |
| Post Translational Modifications | Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated. |
| Function | Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 8Cd30l ReceptorKi-1 AntigenLymphocyte Activation Antigen Cd30Cd Antigen Cd30 |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cytoplasm |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 8 proteinCd30l Receptor proteinKi-1 Antigen proteinLymphocyte Activation Antigen Cd30 proteinCd Antigen Cd30 proteinTNFRSF8 proteinCD30 proteinD1S166E protein |
Information sourced from Uniprot.org
