Human CD243/ABCB1 protein (Recombinant) (N-GST) (STJP003825)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CD243/ABCB1-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ABCB1 |
| Gene ID | 5243 |
| Uniprot ID | MDR1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Phe394-Val672 |
Additional Info
| Function | Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. |
| Protein Name | Atp-Dependent Translocase Abcb1Atp-Binding Cassette Sub-Family B Member 1Multidrug Resistance Protein 1P-Glycoprotein 1Phospholipid Transporter Abcb1Cd Antigen Cd243 |
| Database Links | Reactome: R-HSA-2161517Reactome: R-HSA-382556Reactome: R-HSA-9754706Reactome: R-HSA-9757110 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneCytoplasmAbcb1 Localization Is Influenced By C1orf115 Expression Levels (Plasma Membrane Versus Cytoplasm)Localized To The Apical Membrane Of Enterocytes |
| Alternative Protein Names | Atp-Dependent Translocase Abcb1 proteinAtp-Binding Cassette Sub-Family B Member 1 proteinMultidrug Resistance Protein 1 proteinP-Glycoprotein 1 proteinPhospholipid Transporter Abcb1 proteinCd Antigen Cd243 proteinABCB1 proteinMDR1 proteinPGY1 protein |
Information sourced from Uniprot.org