Human CD243/ABCB1 protein (Recombinant) (N-GST) (STJP003825)

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STJP003825
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD243/ABCB1-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ABCB1
Gene ID: 5243
Uniprot ID: MDR1_HUMAN
Immunogen Region: Phe394-Val672
Immunogen: Homo sapiens (Human)
Function Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Protein Name Atp-Dependent Translocase Abcb1
Atp-Binding Cassette Sub-Family B Member 1
Multidrug Resistance Protein 1
P-Glycoprotein 1
Phospholipid Transporter Abcb1
Cd Antigen Cd243
Database Links Reactome: R-HSA-2161517
Reactome: R-HSA-382556
Reactome: R-HSA-9754706
Reactome: R-HSA-9757110
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Cytoplasm
Abcb1 Localization Is Influenced By C1orf115 Expression Levels (Plasma Membrane Versus Cytoplasm)
Localized To The Apical Membrane Of Enterocytes
Alternative Protein Names Atp-Dependent Translocase Abcb1 protein
Atp-Binding Cassette Sub-Family B Member 1 protein
Multidrug Resistance Protein 1 protein
P-Glycoprotein 1 protein
Phospholipid Transporter Abcb1 protein
Cd Antigen Cd243 protein
ABCB1 protein
MDR1 protein
PGY1 protein

Information sourced from Uniprot.org

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