Human CD1e protein (Recombinant) (His-Tag) (STJP018708)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human CD1e-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.4M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CD1E |
| Gene ID | 913 |
| Uniprot ID | CD1E_HUMAN |
| Accession Number | NP_112155 |
| Immunogen | Human |
| Immunogen Region | 32-305aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSEEQLSFR MLQTSSFANH SWAHSEGSGW LGDLQTHGWD TVLGTIRFLK PWSHGNFSKQ ELKNLQSLFQ LYFHSFIQIV QASAGQFQLE YPFEIQILAG CRMNAPQIFL NMAYQGSDFL SFQGISWEPS PGAGIRAQNI CKVLNRYLDI KEILQSLLGH TCPRFLAGLM EAGESELKRK VKPEAWLSCG PSPGPGRLQL VCHVSGFY |
Additional Info
| Tissue Specificity | Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues. |
| Post Translational Modifications | Mono-ubiquitinated. Proteolytically cleaved in late endosomes to yield a soluble form. |
| Function | T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active. |
| Protein Name | T-Cell Surface Glycoprotein Cd1e - Membrane-AssociatedHcd1eR2g1Cd Antigen Cd1e Cleaved Into - T-Cell Surface Glycoprotein Cd1e - SolubleScd1e |
| Database Links | |
| Cellular Localisation | T-Cell Surface Glycoprotein Cd1eMembrane-Associated: Golgi Apparatus MembraneSingle-Pass Type I Membrane ProteinEarly EndosomeLate EndosomePredominantly Localized In The Trans-Golgi Network In Immature Dendritic CellsAnd As A CleavedSoluble Protein In The Lysosome Lumen Of Mature Dendritic CellsSoluble: Lysosome Lumen |
| Alternative Protein Names | T-Cell Surface Glycoprotein Cd1e - Membrane-Associated proteinHcd1e proteinR2g1 proteinCd Antigen Cd1e Cleaved Into - T-Cell Surface Glycoprotein Cd1e - Soluble proteinScd1e proteinCD1E protein |
Information sourced from Uniprot.org