| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human CD124 (IL4Ra)-protein was developed from hek293. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
0.2 Mu m filtered PBS solution, pH7.2. |
| Storage Instruction: |
Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: |
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Gene Symbol: |
IL4R |
| Gene ID: |
3566 |
| Uniprot ID: |
IL4RA_HUMAN |
| Immunogen Region: |
ECD |
| Immunogen: |
Optimized DNA sequence encoding Human extracellular domain of human CD124including a C-terminal 6His tag was expressed in HEK293 cells. NA |
| Tissue Specificity | Isoform 1 and isoform 2 are highly expressed in activated T-cells. |
| Post Translational Modifications | On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase. |
| Function | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. |
| Protein Name | Interleukin-4 Receptor Subunit AlphaIl-4 Receptor Subunit AlphaIl-4r Subunit AlphaIl-4r-AlphaIl-4raCd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit AlphaSoluble Il-4 Receptor Subunit AlphaSoluble Il-4r-AlphaSil4ralpha/ProtIl-4-Binding ProteinIl4-Bp |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Protein Names | Interleukin-4 Receptor Subunit Alpha proteinIl-4 Receptor Subunit Alpha proteinIl-4r Subunit Alpha proteinIl-4r-Alpha proteinIl-4ra proteinCd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha proteinSoluble Il-4 Receptor Subunit Alpha proteinSoluble Il-4r-Alpha proteinSil4ralpha/Prot proteinIl-4-Binding Protein proteinIl4-Bp proteinIL4R proteinIL4RA protein582J2.1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
