Human CCL15/MIP-1 delta protein (Recombinant) (No-Tag) (STJP017148)

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STJP017148
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CCL15/MIP-1 delta-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Formulation: Liquid in phosphate-Buffered Saline (pH 7.4) 10% Glycerol
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Gene Symbol: CCL15
Gene ID: 6359
Uniprot ID: CCL15_HUMAN
Immunogen Region: 22-113aa
Accession Number: NP_116741
Immunogen: Human
Immunogen Sequence: MQFINDAETE LMMSKLPLEN PVVLNSFHFA ADCCTSYISQ SIPCSLMKSY FETSSECSKP GVIFLTKKGR QVCAKPSGPG VQDCMKKLKP YSI
Tissue Specificity Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.
Post Translational Modifications The N-terminal is proteolytically cleaved by proteases associated with inflammatory responses. The processed forms CCL15(22-92), CCL15(25-92) and CCL15(29-92) exhibit increase in CCR1-mediated signaling and chemotaxis assays in vitro.
Function Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the CCL15.
Protein Name C-C Motif Chemokine 15
Chemokine Cc-2
Hcc-2
Leukotactin-1
Lkn-1
Mip-1 Delta
Macrophage Inflammatory Protein 5
Mip-5
Mrp-2b
Ncc-3
Small-Inducible Cytokine A15 Cleaved Into - Ccl15(22-92 - Ccl15(25-92 - Ccl15(29-92
Database Links
Cellular Localisation Secreted
Alternative Protein Names C-C Motif Chemokine 15 protein
Chemokine Cc-2 protein
Hcc-2 protein
Leukotactin-1 protein
Lkn-1 protein
Mip-1 Delta protein
Macrophage Inflammatory Protein 5 protein
Mip-5 protein
Mrp-2b protein
Ncc-3 protein
Small-Inducible Cytokine A15 Cleaved Into - Ccl15(22-92 - Ccl15(25-92 - Ccl15(29-92 protein
CCL15 protein
MIP5 protein
NCC3 protein
SCYA15 protein

Information sourced from Uniprot.org

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