Human CCL15/MIP-5/HCC-2 protein (Recombinant) (C-6His) (STJP020085)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human CCL15/MIP-5/HCC-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser46-Ile113) of Human CCL15/MIP-5/HCC-2 (Accession #NP_116741.2) fused with His at the C-terminus.
General Information
| Short Description | Recombinant-Human CCL15/MIP-5/HCC-2-C-6His protein was developed in hek293 cells using the region Ser46-Ile113. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.01 EU/Mu g of the protein by LAL method |
Target Information
| Gene Symbol | CCL15 |
| Gene ID | 6359 |
| Uniprot ID | CCL15_HUMAN |
| Immunogen | Recombinant Human CCL15/MIP-5/HCC-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser46-Ile113) of Human CCL15/MIP-5/HCC-2 (Accession #NP_116741.2) fused with His at the C-terminus. |
| Immunogen Region | Ser46-Ile113 |
| Immunogen Sequence | SFHFAADCCTSYISQSIPCS LMKSYFETSSECSKPGVIFL TKKGRQVCAKPSGPGVQDCM KKLKPYSI |
Additional Info
| Tissue Specificity | Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients. |
| Post Translational Modifications | The N-terminal is proteolytically cleaved by proteases associated with inflammatory responses. The processed forms CCL15(22-92), CCL15(25-92) and CCL15(29-92) exhibit increase in CCR1-mediated signaling and chemotaxis assays in vitro. |
| Function | Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the CCL15. |
| Protein Name | C-C Motif Chemokine 15Chemokine Cc-2Hcc-2Leukotactin-1Lkn-1Mip-1 DeltaMacrophage Inflammatory Protein 5Mip-5Mrp-2bNcc-3Small-Inducible Cytokine A15 Cleaved Into - Ccl15(22-92 - Ccl15(25-92 - Ccl15(29-92 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 15 proteinChemokine Cc-2 proteinHcc-2 proteinLeukotactin-1 proteinLkn-1 proteinMip-1 Delta proteinMacrophage Inflammatory Protein 5 proteinMip-5 proteinMrp-2b proteinNcc-3 proteinSmall-Inducible Cytokine A15 Cleaved Into - Ccl15(22-92 - Ccl15(25-92 - Ccl15(29-92 proteinCCL15 proteinMIP5 proteinNCC3 proteinSCYA15 protein |
Information sourced from Uniprot.org