SDS-PAGE gel of recombinant human CCDC101 SGF29 protein under reducing conditions stained with Coomassie blue

Human CCDC101/SGF29 protein (Recombinant) (His-Tag) (STJP017585)

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STJP017585
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Short Description :Recombinant-Human CCDC101/SGF29-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol, 0.1M NaCl
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:SGF29
Gene ID:112869
Uniprot ID:SGF29_HUMAN
Accession Number:NP_612423
Immunogen:Human
Immunogen Region:1-293aa
Immunogen Sequence: MALVSADSRI AELLTELHQL IKQTQEERSR SEHNLVNIQK THERMQTENK ISPYYRTKLR GLYTTAKADA EAECNILRKA LDKIAEIKSL LEERRIAAKI AGLYNDSEPP RKTMRRGVLM TLLQQSAMTL PLWIGKPGDK PPPLCGAIPA SGDYVARPGD KVAARVKAVD GDEQWILAEV VSYSHATNKY EVDDIDEEGK ERHTLS
Function Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me. Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival. Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-506'.
Protein Name Saga-Associated Factor 29
Coiled-Coil Domain-Containing Protein 101
Saga Complex-Associated Factor 29
Database Links Reactome: R-HSA-3214847
Reactome: R-HSA-9772755
Cellular Localisation Nucleus
Alternative Protein Names Saga-Associated Factor 29 protein
Coiled-Coil Domain-Containing Protein 101 protein
Saga Complex-Associated Factor 29 protein
SGF29 protein
CCDC101 protein

Information sourced from Uniprot.org

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