| Function | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. |
| Protein Name | Coiled-Coil And C2 Domain-Containing Protein 1aAkt Kinase-Interacting Protein 1Five Prime Repressor Element Under Dual Repression-Binding Protein 1Fre Under Dual Repression-Binding Protein 1Freud-1Putative Nf-Kappa-B-Activating Protein 023n |
| Cellular Localisation | CytoplasmNucleusCytoskeletonMicrotubule Organizing CenterCentrosome |
| Alternative Protein Names | Coiled-Coil And C2 Domain-Containing Protein 1a proteinAkt Kinase-Interacting Protein 1 proteinFive Prime Repressor Element Under Dual Repression-Binding Protein 1 proteinFre Under Dual Repression-Binding Protein 1 proteinFreud-1 proteinPutative Nf-Kappa-B-Activating Protein 023n proteinCC2D1A proteinAKI1 proteinLGD2 protein |
Information sourced from Uniprot.org
