Human CC2D1A protein (Recombinant) (N-His) (STJP006679)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CC2D1A-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CC2D1A |
| Gene ID | 54862 |
| Uniprot ID | C2D1A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Pro675-Ser944 |
Additional Info
| Function | Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. |
| Protein Name | Coiled-Coil And C2 Domain-Containing Protein 1aAkt Kinase-Interacting Protein 1Five Prime Repressor Element Under Dual Repression-Binding Protein 1Fre Under Dual Repression-Binding Protein 1Freud-1Putative Nf-Kappa-B-Activating Protein 023n |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusCytoskeletonMicrotubule Organizing CenterCentrosome |
| Alternative Protein Names | Coiled-Coil And C2 Domain-Containing Protein 1a proteinAkt Kinase-Interacting Protein 1 proteinFive Prime Repressor Element Under Dual Repression-Binding Protein 1 proteinFre Under Dual Repression-Binding Protein 1 proteinFreud-1 proteinPutative Nf-Kappa-B-Activating Protein 023n proteinCC2D1A proteinAKI1 proteinLGD2 protein |
Information sourced from Uniprot.org