Human Cathepsin S protein (Recombinant) (STJP000491)
SPECIFICATIONS
HostHEK293
ConjugationUnconjugated
ImmunogenOptimized DNA sequence encoding mature chain of human Cathepsin S-CatS (GLN17-ILE331) including a C-terminal His tag was expressed in HEK293 cells. NA
General Information
| Short Description | Recombinant-Human Cathepsin S-protein was developed from hek293. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Formulation | Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction | Can be stored in working aliquots at 2ยฐC-8ยฐC C for one month, or at-20ยฐC to-70ยฐC for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ยตg (1EU/ยตg). NA |
| Immunoreactivity | The activity was tested by the ability to cleave a flourogenic substrate, the measured activity is 300 pmole/ug/min NA |
Target Information
| Gene Symbol | CTSS |
| Gene ID | 1520 |
| Uniprot ID | CATS_HUMAN |
| Immunogen | Optimized DNA sequence encoding mature chain of human Cathepsin S-CatS (GLN17-ILE331) including a C-terminal His tag was expressed in HEK293 cells. NA |
| Immunogen Region | GLN17-ILE331 |
Additional Info
| Function | Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. |
| Protein Name | Cathepsin S |
| Database Links | Reactome: R-HSA-1236977Reactome: R-HSA-1474228Reactome: R-HSA-1679131Reactome: R-HSA-2022090Reactome: R-HSA-2132295Reactome: R-HSA-6798695 |
| Cellular Localisation | LysosomeSecretedCytoplasmic VesiclePhagosome |
| Alternative Protein Names | Cathepsin S proteinCTSS protein |
Information sourced from Uniprot.org