Human Carbonyl reductase 1/CBR1 protein (Recombinant) (No-Tag) (STJP016457)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Carbonyl reductase 1/CBR1-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.5) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CBR1 |
| Gene ID | 873 |
| Uniprot ID | CBR1_HUMAN |
| Accession Number | NP_001748 |
| Immunogen | Human |
| Immunogen Region | 1-277aa |
| Immunogen Sequence | MSSGIHVALV TGGNKGIGLA IVRDLCRLFS GDVVLTARDV TRGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLDVLVNN AGIAFKVADP TPFHIQAEVT MKTNFFGTRD VCTELLPLIK PQGRVVNVSS IMSVRALKSC SPELQQKFRS ETITEEELVG LMNKFVEDTK KGVHQKEGWP SSAYGVTKIG VTVLSRIHAR KLSEQRKGDK ILLNACCP |
Additional Info
| Tissue Specificity | Expressed in kidney (at protein level). |
| Function | NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue. |
| Protein Name | Carbonyl Reductase Nadph 115-Hydroxyprostaglandin Dehydrogenase Nadp(+20-Beta-Hydroxysteroid DehydrogenaseAlcohol Dehydrogenase Nad(P+ Cbr1Nadph-Dependent Carbonyl Reductase 1Prostaglandin 9-KetoreductasePg-9-KrProstaglandin-E(2 9-ReductaseShort Chain Dehydrogenase/Reductase Family 21c Member 1 |
| Database Links | Reactome: R-HSA-2162123 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Carbonyl Reductase Nadph 1 protein15-Hydroxyprostaglandin Dehydrogenase Nadp(+ protein20-Beta-Hydroxysteroid Dehydrogenase proteinAlcohol Dehydrogenase Nad(P+ Cbr1 proteinNadph-Dependent Carbonyl Reductase 1 proteinProstaglandin 9-Ketoreductase proteinPg-9-Kr proteinProstaglandin-E(2 9-Reductase proteinShort Chain Dehydrogenase/Reductase Family 21c Member 1 proteinCBR1 proteinCBR proteinCRN proteinSDR21C1 protein |
Information sourced from Uniprot.org