Human Carbonyl reductase 1/CBR1 protein (Recombinant) (No-Tag) (STJP016457)

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STJP016457
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Carbonyl reductase 1/CBR1-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.5) containing 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: CBR1
Gene ID: 873
Uniprot ID: CBR1_HUMAN
Immunogen Region: 1-277aa
Accession Number: NP_001748
Immunogen: Human
Immunogen Sequence: MSSGIHVALV TGGNKGIGLA IVRDLCRLFS GDVVLTARDV TRGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLDVLVNN AGIAFKVADP TPFHIQAEVT MKTNFFGTRD VCTELLPLIK PQGRVVNVSS IMSVRALKSC SPELQQKFRS ETITEEELVG LMNKFVEDTK KGVHQKEGWP SSAYGVTKIG VTVLSRIHAR KLSEQRKGDK ILLNACCP
Tissue Specificity Expressed in kidney (at protein level).
Function NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue.
Protein Name Carbonyl Reductase Nadph 1
15-Hydroxyprostaglandin Dehydrogenase Nadp(+
20-Beta-Hydroxysteroid Dehydrogenase
Alcohol Dehydrogenase Nad(P+ Cbr1
Nadph-Dependent Carbonyl Reductase 1
Prostaglandin 9-Ketoreductase
Pg-9-Kr
Prostaglandin-E(2 9-Reductase
Short Chain Dehydrogenase/Reductase Family 21c Member 1
Database Links Reactome: R-HSA-2162123
Cellular Localisation Cytoplasm
Alternative Protein Names Carbonyl Reductase Nadph 1 protein
15-Hydroxyprostaglandin Dehydrogenase Nadp(+ protein
20-Beta-Hydroxysteroid Dehydrogenase protein
Alcohol Dehydrogenase Nad(P+ Cbr1 protein
Nadph-Dependent Carbonyl Reductase 1 protein
Prostaglandin 9-Ketoreductase protein
Pg-9-Kr protein
Prostaglandin-E(2 9-Reductase protein
Short Chain Dehydrogenase/Reductase Family 21c Member 1 protein
CBR1 protein
CBR protein
CRN protein
SDR21C1 protein

Information sourced from Uniprot.org

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