| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human BMPR-2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human BMPR2 at 1 Mu g/mL (100 Mu L/well) can bind Human BMP2 with a linear range of 0.015-7.4 Mu g/ml. |
| Gene Symbol: |
BMPR2 |
| Gene ID: |
659 |
| Uniprot ID: |
BMPR2_HUMAN |
| Immunogen: |
Recombinant Human BMPR-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Ile151) of human BMPR2 (Accession #NP_001195.2) fused with a 6×His tag at the C-terminus. |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. |
| Protein Name | Bone Morphogenetic Protein Receptor Type-2Bmp Type-2 ReceptorBmpr-2Bone Morphogenetic Protein Receptor Type IiBmp Type Ii ReceptorBmpr-Ii |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Bone Morphogenetic Protein Receptor Type-2 proteinBmp Type-2 Receptor proteinBmpr-2 proteinBone Morphogenetic Protein Receptor Type Ii proteinBmp Type Ii Receptor proteinBmpr-Ii proteinBMPR2 proteinPPH1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
