Human BMPR-2 protein (Recombinant) (C-His) (STJP001410)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human BMPR-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Ile151) of human BMPR2 (Accession #NP_001195.2) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human BMPR-2-C-His protein was developed in hek293 cells using the region Ser27-Ile151. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized Human BMPR2 at 1 Mu g/mL (100 Mu L/well) can bind Human BMP2 with a linear range of 0.015-7.4 Mu g/ml. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | BMPR2 |
| Gene ID | 659 |
| Uniprot ID | BMPR2_HUMAN |
| Immunogen | Recombinant Human BMPR-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser27-Ile151) of human BMPR2 (Accession #NP_001195.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Ser27-Ile151 |
| Immunogen Sequence | SQNQERLCAFKDPYQQDLGI GESRISHENGTILCSKGSTC YGLWEKSKGDINLVKQGCWS HIGDPQECHYEECVVTTTPP SIQNGTYRFCCCSTDLCNVN FTENFPPPDTTPLSPPHSFN RDETI |
Additional Info
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA. |
| Protein Name | Bone Morphogenetic Protein Receptor Type-2Bmp Type-2 ReceptorBmpr-2Bone Morphogenetic Protein Receptor Type IiBmp Type Ii ReceptorBmpr-Ii |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Bone Morphogenetic Protein Receptor Type-2 proteinBmp Type-2 Receptor proteinBmpr-2 proteinBone Morphogenetic Protein Receptor Type Ii proteinBmp Type Ii Receptor proteinBmpr-Ii proteinBMPR2 proteinPPH1 protein |
Information sourced from Uniprot.org