Human BEND3 protein (Recombinant) (N-His) (STJP016187)

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STJP016187
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Short Description :Recombinant-Human BEND3-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:BEND3
Gene ID:57673
Uniprot ID:BEND3_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Ser383-Val662
Post Translational Modifications Sumoylated at Lys-20 by SUMO1 and at Lys-512 by SUMO1, SUMO2 and SUMO3. Sumoylation probably occurs sequentially, with that of Lys-20 preceding that of Lys-512. It does not alter association with heterochromatin, but is required for the repression of transcription.
Function Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites. Stimulates the ERCC6L translocase and ATPase activities.
Protein Name Ben Domain-Containing Protein 3
Database Links
Cellular Localisation Nucleus
Nucleolus
In The Nucleus
Observed In Heterochromatic Foci Containing Cbx1
Cbx3
Cbx5 And Histone H3 Trimethylated At 'Lys-9'
Released From Chromatin During Decondensation
Association With Heterochromatin Does Not Depend On Sumoylation
Alternative Protein Names Ben Domain-Containing Protein 3 protein
BEND3 protein
KIAA1553 protein

Information sourced from Uniprot.org

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