Human BEND3 protein (Recombinant) (N-His) (STJP016187)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human BEND3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | BEND3 |
| Gene ID | 57673 |
| Uniprot ID | BEND3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser383-Val662 |
Additional Info
| Post Translational Modifications | Sumoylated at Lys-20 by SUMO1 and at Lys-512 by SUMO1, SUMO2 and SUMO3. Sumoylation probably occurs sequentially, with that of Lys-20 preceding that of Lys-512. It does not alter association with heterochromatin, but is required for the repression of transcription. |
| Function | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites. Stimulates the ERCC6L translocase and ATPase activities. |
| Protein Name | Ben Domain-Containing Protein 3 |
| Database Links | |
| Cellular Localisation | NucleusNucleolusIn The NucleusObserved In Heterochromatic Foci Containing Cbx1Cbx3Cbx5 And Histone H3 Trimethylated At 'Lys-9'Released From Chromatin During DecondensationAssociation With Heterochromatin Does Not Depend On Sumoylation |
| Alternative Protein Names | Ben Domain-Containing Protein 3 proteinBEND3 proteinKIAA1553 protein |
Information sourced from Uniprot.org