Human BDH2 protein (Recombinant) (His-Tag) (STJP017020)

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STJP017020
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Short Description :Recombinant-Human BDH2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.1M NaCl
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:BDH2
Gene ID:56898
Uniprot ID:DHRS6_HUMAN
Accession Number:NP_064524
Immunogen:Human
Immunogen Region:1-245aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGRLDGKVII LTAAAQGIGQ AAALAFAREG AKVIATDINE SKLQELEKYP GIQTRVLDVT KKKQIDQFAN EVERLDVLFN VAGFVHHGTV LDCEEKDWDF SMNLNVRSMY LMIKAFLPKM LAQKSGNIIN MSSVASSVKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV DTPSLQERIQ ARGNPEEARN DFLKRQKT
Tissue Specificity Detected in liver (at protein level).
Function NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates. Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines. Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis. May act as a 3-hydroxybutyrate dehydrogenase.
Protein Name Dehydrogenase/Reductase Sdr Family Member 6
(R-Beta-Hydroxybutyrate Dehydrogenase
3-Hydroxybutyrate Dehydrogenase Type 2
4-Oxo-L-Proline Reductase
Oxidoreductase Ucpa
Short Chain Dehydrogenase/Reductase Family 15c Member 1
Database Links Reactome: R-HSA-77111
Cellular Localisation Cytoplasm
Alternative Protein Names Dehydrogenase/Reductase Sdr Family Member 6 protein
(R-Beta-Hydroxybutyrate Dehydrogenase protein
3-Hydroxybutyrate Dehydrogenase Type 2 protein
4-Oxo-L-Proline Reductase protein
Oxidoreductase Ucpa protein
Short Chain Dehydrogenase/Reductase Family 15c Member 1 protein
BDH2 protein
DHRS6 protein
SDR15C1 protein
UNQ6308 protein
PRO20933 protein

Information sourced from Uniprot.org

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