Human BDH2 protein (Recombinant) (His-Tag) (STJP017020)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human BDH2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BDH2 |
| Gene ID | 56898 |
| Uniprot ID | DHRS6_HUMAN |
| Accession Number | NP_064524 |
| Immunogen | Human |
| Immunogen Region | 1-245aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGRLDGKVII LTAAAQGIGQ AAALAFAREG AKVIATDINE SKLQELEKYP GIQTRVLDVT KKKQIDQFAN EVERLDVLFN VAGFVHHGTV LDCEEKDWDF SMNLNVRSMY LMIKAFLPKM LAQKSGNIIN MSSVASSVKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV DTPSLQERIQ ARGNPEEARN DFLKRQKT |
Additional Info
| Tissue Specificity | Detected in liver (at protein level). |
| Function | NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates. Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines. Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis. May act as a 3-hydroxybutyrate dehydrogenase. |
| Protein Name | Dehydrogenase/Reductase Sdr Family Member 6(R-Beta-Hydroxybutyrate Dehydrogenase3-Hydroxybutyrate Dehydrogenase Type 24-Oxo-L-Proline ReductaseOxidoreductase UcpaShort Chain Dehydrogenase/Reductase Family 15c Member 1 |
| Database Links | Reactome: R-HSA-77111 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Dehydrogenase/Reductase Sdr Family Member 6 protein(R-Beta-Hydroxybutyrate Dehydrogenase protein3-Hydroxybutyrate Dehydrogenase Type 2 protein4-Oxo-L-Proline Reductase proteinOxidoreductase Ucpa proteinShort Chain Dehydrogenase/Reductase Family 15c Member 1 proteinBDH2 proteinDHRS6 proteinSDR15C1 proteinUNQ6308 proteinPRO20933 protein |
Information sourced from Uniprot.org