Human BCKDHA protein (Recombinant) (N-His) (STJP010863)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human BCKDHA-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | BCKDHA |
| Gene ID | 593 |
| Uniprot ID | ODBA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu97-Lys400 |
Additional Info
| Function | Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction. |
| Protein Name | 2-Oxoisovalerate Dehydrogenase Subunit Alpha - MitochondrialBranched-Chain Alpha-Keto Acid Dehydrogenase E1 Component Alpha ChainBckde1aBckdh E1-Alpha |
| Database Links | Reactome: R-HSA-70895Reactome: R-HSA-9859138Reactome: R-HSA-9865113Reactome: R-HSA-9865125Reactome: R-HSA-9907570Reactome: R-HSA-9912481Reactome: R-HSA-9912529 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Protein Names | 2-Oxoisovalerate Dehydrogenase Subunit Alpha - Mitochondrial proteinBranched-Chain Alpha-Keto Acid Dehydrogenase E1 Component Alpha Chain proteinBckde1a proteinBckdh E1-Alpha proteinBCKDHA protein |
Information sourced from Uniprot.org