Human BCKDHA protein (Recombinant) (N-His) (STJP010863)

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STJP010863
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human BCKDHA-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: BCKDHA
Gene ID: 593
Uniprot ID: ODBA_HUMAN
Immunogen Region: Leu97-Lys400
Immunogen: Homo sapiens (Human)
Function Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.
Protein Name 2-Oxoisovalerate Dehydrogenase Subunit Alpha - Mitochondrial
Branched-Chain Alpha-Keto Acid Dehydrogenase E1 Component Alpha Chain
Bckde1a
Bckdh E1-Alpha
Database Links Reactome: R-HSA-70895
Reactome: R-HSA-9859138
Cellular Localisation Mitochondrion Matrix
Alternative Protein Names 2-Oxoisovalerate Dehydrogenase Subunit Alpha - Mitochondrial protein
Branched-Chain Alpha-Keto Acid Dehydrogenase E1 Component Alpha Chain protein
Bckde1a protein
Bckdh E1-Alpha protein
BCKDHA protein

Information sourced from Uniprot.org

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