Name: Human BCKDHA protein (Recombinant) (His-Tag) (STJP017081)
SKU: STJP017081
Availability: InStock

Human BCKDHA protein (Recombinant) (His-Tag) (STJP017081)

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STJP017081

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Short Description :	Recombinant-Human BCKDHA-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:	SDS-PAGE
Host:	E.coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration:	0.25 mg/mL
Formulation:	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 30% Glycerol, 0.2M NaCl
Storage Instruction:	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BCKDHA
Gene ID:	593
Uniprot ID:	ODBA_HUMAN
Accession Number:	NP_000700.1
Immunogen:	Human
Immunogen Region:	46-445aa
Immunogen Sequence:	MSSLDDKPQF PGASAEFIDK LEFIQPNVIS GIPIYRVMDR QGQIINPSED PHLPKEKVLK LYKSMTLLNT MDRILYESQR QGRISFYMTN YGEEGTHVGS AAALDNTDLV FGQYREAGVL MYRDYPLELF MAQCYGNISD LGKGRQMPVH YGCKERHFVT ISSPLATQIP QAVGAAYAAK RANANRVVIC YFGEGAASEG DAHAGF

Post Translational Modifications	Phosphorylated at Ser-337 by BCKDK and dephosphorylated by protein phosphatase PPM1K.
Function	Together with BCKDHB forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.
Protein Name	2-Oxoisovalerate Dehydrogenase Subunit Alpha - Mitochondrial Branched-Chain Alpha-Keto Acid Dehydrogenase E1 Component Alpha Chain Bckde1a Bckdh E1-Alpha
Database Links	Reactome: R-HSA-70895 Reactome: R-HSA-9859138 Reactome: R-HSA-9865113 Reactome: R-HSA-9865125 Reactome: R-HSA-9907570 Reactome: R-HSA-9912481 Reactome: R-HSA-9912529
Cellular Localisation	Mitochondrion Matrix
Alternative Protein Names	2-Oxoisovalerate Dehydrogenase Subunit Alpha - Mitochondrial protein Branched-Chain Alpha-Keto Acid Dehydrogenase E1 Component Alpha Chain protein Bckde1a protein Bckdh E1-Alpha protein BCKDHA protein

Information sourced from Uniprot.org

Model	Name	Host	Application
STJP010863	Human BCKDHA protein (Recombinant) (N-His) (STJP010863)	E.coli	ELISA/Immunogen/SDS-PAGE/WB
STJP018173	Human CYB5R1 protein (Recombinant) (His-Tag) (STJP018173)	E.coli	SDS-PAGE
STJP018195	Human OCIAD2 protein (Recombinant) (His-Tag) (STJP018195)	E.coli	SDS-PAGE/Denatured
STJP018193	Human HINT2 protein (Recombinant) (His-Tag) (STJP018193)	E.coli	SDS-PAGE
STJP018182	Human PDZK1 protein (Recombinant) (His-Tag) (STJP018182)	E.coli	SDS-PAGE

Human BCKDHA protein (Recombinant) (His-Tag) (STJP017081)

General Information