Human BCAM (Basal cell adhesion molecule) Sandwich ELISA Kit (STJE0020122)

Human BCAM (Basal cell adhesion molecule) Sandwich ELISA Kit (STJE0020122)

SKU:
STJE0020122-96
£444.50
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Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Sensitivity: 46.875 pg/mL
Detection Limit: 78.125-5000 pg/mL
Storage Instruction: Store unopened box at 2-8 °C for up to 1 month. For longer storage check individual components.
Assay Time: 4 hours
Gene Symbol: BCAM
Gene ID: 4059
Uniprot ID: BCAM_HUMAN
Specificity: This Sandwich ELISA kit recognizes Human Basal cell adhesion molecule in various sample types. No significant cross-reactivity or interference was observed between Human BCAM analogues.
Sample Type: Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Tissue Specificity Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.
Post Translational Modifications Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin. Ser-621 can also be phosphorylated by AKT1.
Function Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR.
Protein Name Basal Cell Adhesion Molecule
Auberger B Antigen
B-Cam Cell Surface Glycoprotein
F8/G253 Antigen
Lutheran Antigen
Lutheran Blood Group Glycoprotein
Cd Antigen Cd239
Database Links
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative ELISA Names Basal Cell Adhesion Molecule ELISA kit
Auberger B Antigen ELISA kit
B-Cam Cell Surface Glycoprotein ELISA kit
F8/G253 Antigen ELISA kit
Lutheran Antigen ELISA kit
Lutheran Blood Group Glycoprotein ELISA kit
Cd Antigen Cd239 ELISA kit
BCAM ELISA kit
LU ELISA kit
MSK19 ELISA kit
output

Information sourced from Uniprot.org

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