Human BCAM (Basal cell adhesion molecule) Sandwich ELISA Kit (STJE0020122)
SPECIFICATIONS
General Information
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 46.875 pg/mL |
| Detection Limit | 78.125-5000 pg/mL |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Storage Instruction | Store unopened box at 2-8 °C for up to 1 month. For longer storage check individual components. |
| Assay Time | 4 hours |
Target Information
| Gene Symbol | BCAM |
| Gene ID | 4059 |
| Uniprot ID | BCAM_HUMAN |
| Specificity | This Sandwich ELISA kit recognizes Human Basal cell adhesion molecule in various sample types. No significant cross-reactivity or interference was observed between Human BCAM analogues. |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
Additional Info
| Tissue Specificity | Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls. |
| Post Translational Modifications | Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin. Ser-621 can also be phosphorylated by AKT1. |
| Function | Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR. |
| Protein Name | Basal Cell Adhesion MoleculeAuberger B AntigenB-Cam Cell Surface GlycoproteinF8/G253 AntigenLutheran AntigenLutheran Blood Group GlycoproteinCd Antigen Cd239 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative ELISA Names | Basal Cell Adhesion Molecule ELISA kitAuberger B Antigen ELISA kitB-Cam Cell Surface Glycoprotein ELISA kitF8/G253 Antigen ELISA kitLutheran Antigen ELISA kitLutheran Blood Group Glycoprotein ELISA kitCd Antigen Cd239 ELISA kitBCAM ELISA kitLU ELISA kitMSK19 ELISA kit |
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Information sourced from Uniprot.org