| Short Description : | Recombinant-Human B7-DC/PD-L2/CD273-C-hFc & His protein was developed in hek293 cells using the region Leu20-Pro219. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human PD-1 at 5 Mu g/mL (100 Mu L/well) can bind Recombinant Human PD-L2 with a linear range of 0.06-0.24 Mu g/mL. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | PDCD1LG2 |
| Gene ID: | 80380 |
| Uniprot ID: | PD1L2_HUMAN |
| Immunogen: | Recombinant Human PD-L2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu20-Pro219) of human PD-L2 (Accession #NP_079515.2) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Region: | Leu20-Pro219 |
| Immunogen Sequence: | LFTVTVPKELYIIEHGSNVT LECNFDTGSHVNLGAITASL QKVENDTSPHRERATLLEEQ LPLGKASFHIPQVQVRDEGQ YQCIIIYGVAWDYKYLTLKV KASYRKINTHILKVPETDEV ELTCQATGYPLAEVSWPNVS VPANTSHSRTPEGLYQVTSV LRLKPPPGRNFSCVFWNTHV RELTLASIDLQSQMEPRTHP |
| Function | Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. |
| Protein Name | Programmed Cell Death 1 Ligand 2Pd-1 Ligand 2Pd-L2Pdcd1 Ligand 2Programmed Death Ligand 2Butyrophilin B7-DcB7-DcCd Antigen Cd273 |
| Database Links | Reactome: R-HSA-389948 |
| Cellular Localisation | Isoform 3: SecretedIsoform 2: Endomembrane SystemSingle-Pass Type I Membrane ProteinIsoform 1: Cell Membrane |
| Alternative Protein Names | Programmed Cell Death 1 Ligand 2 proteinPd-1 Ligand 2 proteinPd-L2 proteinPdcd1 Ligand 2 proteinProgrammed Death Ligand 2 proteinButyrophilin B7-Dc proteinB7-Dc proteinCd Antigen Cd273 proteinPDCD1LG2 proteinB7DC proteinCD273 proteinPDCD1L2 proteinPDL2 protein |
Information sourced from Uniprot.org
