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Human B7-DC/PD-L2/CD273 protein (Recombinant) (C-hFc & His) (STJP002677)

Human B7-DC/PD-L2/CD273 protein (Recombinant) (C-hFc & His) (STJP002677)

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STJP002677

£59.50 - £189.50

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General Information
Product Properties
Target Information
Additional Info
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Host:	HEK293 cells
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Recombinant-Human B7-DC/PD-L2/CD273-C-hFc & His protein was developed from hek293 cells and has a target region of C-hFc & His. For use in research applications.

Formulation:	Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human PD-1 at 5 Mu g/mL (100 Mu L/well) can bind Recombinant Human PD-L2 with a linear range of 0.06-0.24 Mu g/mL.

Gene Symbol:	PDCD1LG2
Gene ID:	80380
Uniprot ID:	PD1L2_HUMAN
Immunogen Region:	Leu20-Pro219
Immunogen:	Recombinant Human PD-L2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu20-Pro219) of human PD-L2 (Accession #NP_079515.2) fused with an Fc, 6×His tag at the C-terminus.

Function	Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
Protein Name	Programmed Cell Death 1 Ligand 2 Pd-1 Ligand 2 Pd-L2 Pdcd1 Ligand 2 Programmed Death Ligand 2 Butyrophilin B7-Dc B7-Dc Cd Antigen Cd273
Database Links	Reactome: R-HSA-389948
Cellular Localisation	Isoform 3: Secreted Isoform 2: Endomembrane System Single-Pass Type I Membrane Protein Isoform 1: Cell Membrane
Alternative Protein Names	Programmed Cell Death 1 Ligand 2 protein Pd-1 Ligand 2 protein Pd-L2 protein Pdcd1 Ligand 2 protein Programmed Death Ligand 2 protein Butyrophilin B7-Dc protein B7-Dc protein Cd Antigen Cd273 protein PDCD1LG2 protein B7DC protein CD273 protein PDCD1L2 protein PDL2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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