Human ARPP19 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP008239)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ARPP19-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ARPP19 |
| Gene ID | 10776 |
| Uniprot ID | ARP19_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser2-Leu77 |
Additional Info
| Function | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Inhibition of PP2A is enhanced when ARPP19 is phosphorylated. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. |
| Protein Name | Camp-Regulated Phosphoprotein 19Arpp-19 |
| Database Links | Reactome: R-HSA-2465910 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Camp-Regulated Phosphoprotein 19 proteinArpp-19 proteinARPP19 protein |
Information sourced from Uniprot.org