| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human ARPP19-N-His-SUMO & C-Strep protein was developed from e. coli and has a target region of N-His-SUMO & C-Strep. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | ARPP19 |
| Gene ID: | 10776 |
| Uniprot ID: | ARP19_HUMAN |
| Immunogen Region: | Ser2-Leu77 |
| Immunogen: | Homo sapiens (Human) |
| Function | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. |
| Protein Name | Camp-Regulated Phosphoprotein 19Arpp-19 |
| Database Links | Reactome: R-HSA-2465910 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Camp-Regulated Phosphoprotein 19 proteinArpp-19 proteinARPP19 protein |
Information sourced from Uniprot.org