Human Angiopoietin-like 7/ANGPTL7 protein (Recombinant) (C-His) (STJP000978)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Angiopoietin-like 7/ANGPTL7 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln27-Pro346) of human Angiopoietin-like 7 (Accession #NP_066969.1) fused with a 6×His tag at the C-te
General Information
| Short Description | Recombinant-Human Angiopoietin-like 7/ANGPTL7-C-His protein was developed in hek293 cells using the region Gln27-Pro346. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human ANGPTL7 at 5 Mu g/mL (100 Mu L/well) can bind Recombinant Human LILRB4 with a linear range of 0.5-3.5 Mu g/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | ANGPTL7 |
| Gene ID | 10218 |
| Uniprot ID | ANGL7_HUMAN |
| Immunogen | Recombinant Human Angiopoietin-like 7/ANGPTL7 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln27-Pro346) of human Angiopoietin-like 7 (Accession #NP_066969.1) fused with a 6×His tag at the C-te |
| Immunogen Region | Gln27-Pro346 |
| Immunogen Sequence | QKLSKHKTPAQPQLKAANCC EEVKELKAQVANLSSLLSEL NKKQERDWVSVVMQVMELES NSKRMESRLTDAESKYSEMN NQIDIMQLQAAQTVTQTSAD AIYDCSSLYQKNYRISGVYK LPPDDFLGSPELEVFCDMET SGGGWTIIQRRKSGLVSFYR DWKQYKQGFGSIRGDFWLGN EHIHRLSRQPTRLRVEMEDW EGNLRYAEYSHFVLGNELNS YRLFLGNYTGNVGNDALQY |
Additional Info
| Tissue Specificity | Highly expressed in the cornea (at protein level). Expression is restricted to the stromal layer. Also detected at the junction between the corneal stromal layer and the conjuctiva. Not detected in the sclera. |
| Function | Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure. Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency. |
| Protein Name | Angiopoietin-Related Protein 7Angiopoietin-Like FactorAngiopoietin-Like Protein 7Cornea-Derived Transcript 6 Protein |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Angiopoietin-Related Protein 7 proteinAngiopoietin-Like Factor proteinAngiopoietin-Like Protein 7 proteinCornea-Derived Transcript 6 Protein proteinANGPTL7 proteinCDT6 proteinUNQ313 proteinPRO356 protein |
Information sourced from Uniprot.org