Host: |
HEK293 cells |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Recombinant-Human Aminopeptidase N/CD13-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Immunoreactivity: |
Measured by its ability to cleave the fluorogenic peptide substrate, Ala-7-amido-4-methylcoumarin (Ala-AMC). The specific activity is >4300 pmol/min/Mu g. |
Gene Symbol: |
ANPEP |
Gene ID: |
290 |
Uniprot ID: |
AMPN_HUMAN |
Immunogen Region: |
Lys69-Lys967 |
Immunogen: |
Recombinant Human Aminopeptidase N/CD13 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys69-Lys967) of human ANPEP/CD13 (Accession #NP_001141.2) fused with an 8×His tag at the C-terminus. |
Post Translational Modifications | Sulfated. N- and O-glycosylated. May undergo proteolysis and give rise to a soluble form. |
Function | Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity. (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection. |
Protein Name | Aminopeptidase NAp-NHapnAlanyl AminopeptidaseAminopeptidase MAp-MMicrosomal AminopeptidaseMyeloid Plasma Membrane Glycoprotein Cd13Gp150Cd Antigen Cd13 |
Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-6798695 |
Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinAlso Found As A Soluble Form |
Alternative Protein Names | Aminopeptidase N proteinAp-N proteinHapn proteinAlanyl Aminopeptidase proteinAminopeptidase M proteinAp-M proteinMicrosomal Aminopeptidase proteinMyeloid Plasma Membrane Glycoprotein Cd13 proteinGp150 proteinCd Antigen Cd13 proteinANPEP proteinAPN proteinCD13 proteinPEPN protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance