Human ALK-7/ACVR1C protein (Recombinant) (C-hFc&His) (STJP001023)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human ALK-7/ACVR1C Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu22-Glu113) of human ALK-7 Protein (Accession #NP_660302.2) fused with an Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human ALK-7/ACVR1C-C-hFc&His protein was developed in hek293 cells using the region Leu22-Glu113. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | ACVR1C |
| Gene ID | 130399 |
| Uniprot ID | ACV1C_HUMAN |
| Immunogen | Recombinant Human ALK-7/ACVR1C Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu22-Glu113) of human ALK-7 Protein (Accession #NP_660302.2) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Leu22-Glu113 |
| Immunogen Sequence | LSPGLKCVCLLCDSSNFTCQ TEGACWASVMLTNGKEQVIK SCVSLPELNAQVFCHSSNNV TKTECCFTDFCNNITLHLPT ASPNAPKLGPME |
Additional Info
| Function | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells. Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression. |
| Protein Name | Activin Receptor Type-1cActivin Receptor Type IcActr-IcActivin Receptor-Like Kinase 7Alk-7 |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-1433617Reactome: R-HSA-1502540 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Activin Receptor Type-1c proteinActivin Receptor Type Ic proteinActr-Ic proteinActivin Receptor-Like Kinase 7 proteinAlk-7 proteinACVR1C proteinALK7 protein |
Information sourced from Uniprot.org