Human AK4 (C22S) protein (Recombinant) (His-Tag) (STJP016411)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human AK4 (C22S)-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.5) containing 2mM DTT, 30% Glycerol, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AK4 |
| Gene ID | 205 |
| Uniprot ID | KAD4_HUMAN |
| Accession Number | NP_982289 |
| Immunogen | Human |
| Immunogen Region | 1-223aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain. |
| Function | Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions. Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP. Phosphorylates only AMP when using GTP as phosphate donor. In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor. Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors. Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK. Plays a protective role in the cellular response to oxidative stress. |
| Protein Name | Adenylate Kinase 4 - MitochondrialAdenylate Kinase 3-LikeGtp -Amp Phosphotransferase Ak4 |
| Database Links | Reactome: R-HSA-499943 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Protein Names | Adenylate Kinase 4 - Mitochondrial proteinAdenylate Kinase 3-Like proteinGtp -Amp Phosphotransferase Ak4 proteinAK4 proteinAK3 proteinAK3L1 protein |
Information sourced from Uniprot.org