Human AIMP2 protein (Recombinant) (N-His) (STJP007430)

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STJP007430
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AIMP2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: AIMP2
Gene ID: 7965
Uniprot ID: AIMP2_HUMAN
Immunogen Region: Lys120-Lys320
Immunogen: Homo sapiens (Human)
Function Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Protein Name Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 2
Multisynthase Complex Auxiliary Component P38
Protein Jtv-1
Database Links Reactome: R-HSA-2408522
Reactome: R-HSA-379716
Reactome: R-HSA-9856649
Cellular Localisation Cytoplasm
Cytosol
Nucleus
Following Dna Damage
Dissociates From The Aminoacyl-Trna Synthase Complex And Translocates From The Cytoplasm To The Nucleus
Alternative Protein Names Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 2 protein
Multisynthase Complex Auxiliary Component P38 protein
Protein Jtv-1 protein
AIMP2 protein
JTV1 protein
PRO0992 protein

Information sourced from Uniprot.org

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