Human AIMP2 protein (Recombinant) (N-His) (STJP007430)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human AIMP2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | AIMP2 |
| Gene ID | 7965 |
| Uniprot ID | AIMP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys120-Lys320 |
Additional Info
| Function | Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. |
| Protein Name | Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 2Multisynthase Complex Auxiliary Component P38Protein Jtv-1 |
| Database Links | Reactome: R-HSA-2408522Reactome: R-HSA-379716Reactome: R-HSA-9856649 |
| Cellular Localisation | CytoplasmCytosolNucleusFollowing Dna DamageDissociates From The Aminoacyl-Trna Synthase Complex And Translocates From The Cytoplasm To The Nucleus |
| Alternative Protein Names | Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 2 proteinMultisynthase Complex Auxiliary Component P38 proteinProtein Jtv-1 proteinAIMP2 proteinJTV1 proteinPRO0992 protein |
Information sourced from Uniprot.org