Human ADI1 protein (Recombinant) (N-His) (STJP007852)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ADI1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ADI1 |
| Gene ID | 55256 |
| Uniprot ID | MTND_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ala179 |
Additional Info
| Function | Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. |
| Protein Name | Acireductone DioxygenaseAcireductone DioxygenaseFe(2+-RequiringArd'Fe-ArdAcireductone DioxygenaseNi(2+-RequiringArdNi-ArdMembrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1Mtcbp-1Submergence-Induced Protein-Like FactorSip-L |
| Database Links | Reactome: R-HSA-1237112 |
| Cellular Localisation | CytoplasmNucleusCell MembranePeripheral Membrane ProteinCytoplasmic SideLocalizes To The Plasma Membrane When Complexed To Mmp14 |
| Alternative Protein Names | Acireductone Dioxygenase proteinAcireductone Dioxygenase proteinFe(2+-Requiring proteinArd' proteinFe-Ard proteinAcireductone Dioxygenase proteinNi(2+-Requiring proteinArd proteinNi-Ard proteinMembrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1 proteinMtcbp-1 proteinSubmergence-Induced Protein-Like Factor proteinSip-L proteinADI1 proteinMTCBP1 proteinHMFT1638 protein |
Information sourced from Uniprot.org