Human ADI1 protein (Recombinant) (N-His) (STJP007852)

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STJP007852
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ADI1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ADI1
Gene ID: 55256
Uniprot ID: MTND_HUMAN
Immunogen Region: Met1-Ala179
Immunogen: Homo sapiens (Human)
Function Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.
Protein Name Acireductone Dioxygenase
Acireductone Dioxygenase
Fe(2+-Requiring
Ard'
Fe-Ard
Acireductone Dioxygenase
Ni(2+-Requiring
Ard
Ni-Ard
Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1
Mtcbp-1
Submergence-Induced Protein-Like Factor
Sip-L
Database Links Reactome: R-HSA-1237112
Cellular Localisation Cytoplasm
Nucleus
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Localizes To The Plasma Membrane When Complexed To Mmp14
Alternative Protein Names Acireductone Dioxygenase protein
Acireductone Dioxygenase protein
Fe(2+-Requiring protein
Ard' protein
Fe-Ard protein
Acireductone Dioxygenase protein
Ni(2+-Requiring protein
Ard protein
Ni-Ard protein
Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1 protein
Mtcbp-1 protein
Submergence-Induced Protein-Like Factor protein
Sip-L protein
ADI1 protein
MTCBP1 protein
HMFT1638 protein

Information sourced from Uniprot.org

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