Human 15-PGDH/HPGD protein (Recombinant) (His-Tag) (STJP016859)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human 15-PGDH/HPGD-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HPGD |
| Gene ID | 3248 |
| Uniprot ID | PGDH_HUMAN |
| Accession Number | NP_000851 |
| Immunogen | Human |
| Immunogen Region | 1-266aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Detected in colon epithelium (at protein level). |
| Function | Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation. |
| Protein Name | 15-Hydroxyprostaglandin Dehydrogenase Nad(+15-PgdhEicosanoid/Docosanoid Dehydrogenase Nad(+Prostaglandin Dehydrogenase 1Short Chain Dehydrogenase/Reductase Family 36c Member 1 |
| Database Links | Reactome: R-HSA-2142700Reactome: R-HSA-2162123Reactome: R-HSA-9018676Reactome: R-HSA-9018896 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | 15-Hydroxyprostaglandin Dehydrogenase Nad(+ protein15-Pgdh proteinEicosanoid/Docosanoid Dehydrogenase Nad(+ proteinProstaglandin Dehydrogenase 1 proteinShort Chain Dehydrogenase/Reductase Family 36c Member 1 proteinHPGD proteinPGDH1 proteinSDR36C1 protein |
Information sourced from Uniprot.org