SDS-PAGE gel showing recombinant human 15-PGDH HPGD protein 3µg under reducing conditions with Coomassie blue staining

Human 15-PGDH/HPGD protein (Recombinant) (His-Tag) (STJP016859)

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STJP016859
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Short Description :Recombinant-Human 15-PGDH/HPGD-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:HPGD
Gene ID:3248
Uniprot ID:PGDH_HUMAN
Accession Number:NP_000851
Immunogen:Human
Immunogen Region:1-266aa
Immunogen Sequence: MHVNGKVALV TGAAQGIGRA FAEALLLKGA KVALVDWNLE AGVQCKAALD EQFEPQKTLF IQCDVADQQQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW EKTLQINLVS VISGTYLGLD YMSKQNGGEG GIIINMSSLA GLMPVAQQPV YCASKHGIVG FTRSAALAAN LMNSGVRLNA ICPGFVNTAI LESIEKEENM GQYIEY
Tissue Specificity Detected in colon epithelium (at protein level).
Function Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.
Protein Name 15-Hydroxyprostaglandin Dehydrogenase Nad(+
15-Pgdh
Eicosanoid/Docosanoid Dehydrogenase Nad(+
Prostaglandin Dehydrogenase 1
Short Chain Dehydrogenase/Reductase Family 36c Member 1
Database Links Reactome: R-HSA-2142700
Reactome: R-HSA-2162123
Reactome: R-HSA-9018676
Reactome: R-HSA-9018896
Cellular Localisation Cytoplasm
Alternative Protein Names 15-Hydroxyprostaglandin Dehydrogenase Nad(+ protein
15-Pgdh protein
Eicosanoid/Docosanoid Dehydrogenase Nad(+ protein
Prostaglandin Dehydrogenase 1 protein
Short Chain Dehydrogenase/Reductase Family 36c Member 1 protein
HPGD protein
PGDH1 protein
SDR36C1 protein

Information sourced from Uniprot.org

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