Granzyme B Blocking Peptide peptide (STJ504165)

SKU:
STJ504165-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Granzyme B Blocking Peptide is synthetically produced from the 50-100 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: GZMB
Gene ID: 3002
Uniprot ID: GRAB_HUMAN
Immunogen Region: 50-100
Immunogen: Synthetic peptide taken within amino acid region 50-100 on human endogenous Granzyme B protein.
Function Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair.
Peptide Name Granzyme B
C11
Ctla-1
Cathepsin G-Like 1
Ctsgl1
Cytotoxic T-Lymphocyte Proteinase 2
Lymphocyte Protease
Fragmentin-2
Granzyme-2
Human Lymphocyte Protein
Hlp
Sect
T-Cell Serine Protease 1-3e
Database Links Reactome: R-HSA-2197563
Reactome: R-HSA-5620971
Reactome: R-HSA-75108
Cellular Localisation Secreted
Cytolytic Granule
Delivered Into The Target Cell By Perforin
Alternative Peptide Names Granzyme B protein
C11 protein
Ctla-1 protein
Cathepsin G-Like 1 protein
Ctsgl1 protein
Cytotoxic T-Lymphocyte Proteinase 2 protein
Lymphocyte Protease protein
Fragmentin-2 protein
Granzyme-2 protein
Human Lymphocyte Protein protein
Hlp protein
Sect protein
T-Cell Serine Protease 1-3e protein
GZMB protein
CGL1 protein
CSPB protein
CTLA1 protein
GRB protein

Information sourced from Uniprot.org

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