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Granzyme B Blocking Peptide peptide (STJ504165)

Granzyme B Blocking Peptide peptide (STJ504165)

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STJ504165-250

£289.50

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General Information
Product Properties
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Additional Info
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Applications:	Immunodepletion/Immunocompetition
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Granzyme B Blocking Peptide is synthetically produced from the 50-100 sequence and is suitable for use in western blot applications.

Formulation:	Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	GZMB
Gene ID:	3002
Uniprot ID:	GRAB_HUMAN
Immunogen Region:	50-100
Immunogen:	Synthetic peptide taken within amino acid region 50-100 on human endogenous Granzyme B protein.

Function	Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair.
Peptide Name	Granzyme B C11 Ctla-1 Cathepsin G-Like 1 Ctsgl1 Cytotoxic T-Lymphocyte Proteinase 2 Lymphocyte Protease Fragmentin-2 Granzyme-2 Human Lymphocyte Protein Hlp Sect T-Cell Serine Protease 1-3e
Database Links	Reactome: R-HSA-2197563 Reactome: R-HSA-5620971 Reactome: R-HSA-75108
Cellular Localisation	Secreted Cytolytic Granule Delivered Into The Target Cell By Perforin
Alternative Peptide Names	Granzyme B protein C11 protein Ctla-1 protein Cathepsin G-Like 1 protein Ctsgl1 protein Cytotoxic T-Lymphocyte Proteinase 2 protein Lymphocyte Protease protein Fragmentin-2 protein Granzyme-2 protein Human Lymphocyte Protein protein Hlp protein Sect protein T-Cell Serine Protease 1-3e protein GZMB protein CGL1 protein CSPB protein CTLA1 protein GRB protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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