| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Glucose transporter GLUT5 Blocking Peptide is synthetically produced from the 490-500 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
SLC2A5 |
| Gene ID: |
6518 |
| Uniprot ID: |
GTR5_HUMAN |
| Immunogen Region: |
490-500 |
| Immunogen: |
Synthetic peptide corresponding to C terminal amino acids 490-500 of Human Glucose Transporter 5 GLUT5. A cysteine residue was included at the N-terminus of the peptide to accommodate KLH conjugation. Sequence: ELKEPPVTSEQ |
| Tissue Specificity | Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue. |
| Function | Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of 2-deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake. |
| Peptide Name | Solute Carrier Family 2 - Facilitated Glucose Transporter Member 5Fructose TransporterGlucose Transporter Type 5 - Small IntestineGlut-5 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8981373 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneSarcolemmaLocalized On The Apical Membrane Of Jejunum VilliBut Also On Lateral Plasma Membranes Of The VilliTransport To The Cell Membrane Is Dependent On Rab11a |
| Alternative Peptide Names | Solute Carrier Family 2 - Facilitated Glucose Transporter Member 5 proteinFructose Transporter proteinGlucose Transporter Type 5 - Small Intestine proteinGlut-5 proteinSLC2A5 proteinGLUT5 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
