GFRA-1 protein (STJP000149)

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STJP000149
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Short Description :GFRA-1-protein was developed from. For use in research applications.
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.9 mg/ml
Purification:Purified by Ni-affinity chromatography and gel-filtration from serum-free CHO growth media
Formulation:PBS pH 7.4
Storage Instruction:Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles
Gene Symbol:GFRA1
Gene ID:2674
Uniprot ID:GFRA1_HUMAN
Function Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor.
Protein Name Gdnf Family Receptor Alpha-1
Gdnf Receptor Alpha-1
Gdnfr-Alpha-1
Gfr-Alpha-1
Ret Ligand 1
Tgf-Beta-Related Neurotrophic Factor Receptor 1
Database Links Reactome: R-HSA-419037
Reactome: R-HSA-5673001
Reactome: R-HSA-8853659
Reactome: R-HSA-9830674
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Golgi Apparatus
Trans-Golgi Network
Endosome
Multivesicular Body
Localizes Mainly To The Plasma Membrane
In The Presence Of Sorl1
Shifts To Vesicular Structures
Including Trans-Golgi Network
Endosomes And Multivesicular Bodies
Alternative Protein Names Gdnf Family Receptor Alpha-1 protein
Gdnf Receptor Alpha-1 protein
Gdnfr-Alpha-1 protein
Gfr-Alpha-1 protein
Ret Ligand 1 protein
Tgf-Beta-Related Neurotrophic Factor Receptor 1 protein
GFRA1 protein
GDNFRA protein
RETL1 protein
TRNR1 protein

Information sourced from Uniprot.org

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