| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
DDX6 Positive Control for STJ500746 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
DDX6 |
| Gene ID: |
1656 |
| Uniprot ID: |
DDX6_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with DDX6 antibody STJ500746. |
| Tissue Specificity | Abundantly expressed in most tissues. |
| Post Translational Modifications | Sumoylated. |
| Function | Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. |
| Peptide Name | Probable Atp-Dependent Rna Helicase Ddx6Atp-Dependent Rna Helicase P54Dead Box Protein 6Oncogene Rck |
| Database Links | Reactome: R-HSA-430039 |
| Cellular Localisation | CytoplasmP-BodyNucleusImported In The Nucleus Via Interaction With Eif4enif1/4e-T Via A Piggy-Back MechanismUpon Cellular StressRelocalizes To Stress Granules |
| Alternative Peptide Names | Probable Atp-Dependent Rna Helicase Ddx6 proteinAtp-Dependent Rna Helicase P54 proteinDead Box Protein 6 proteinOncogene Rck proteinDDX6 proteinHLR2 proteinRCK protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
