CXCR2 Blocking Peptide for STJ500650 peptide (STJ503881)

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STJ503881-250
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Short Description :CXCR2 Blocking Peptide for STJ500650 is synthetically produced from the 18-39 sequence and is suitable for use in western blot applications.
Applications:Immunodepletion/Immunocompetition
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation:Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction:Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol:CXCR2
Gene ID:3579
Uniprot ID:CXCR2_HUMAN
Immunogen:Synthetic peptide: EDLSNYSYSSTLPPFLLDAAPC Corresponding to amino acids 18-39 of Human CXCR2.
Immunogen Region:18-39
Specificity:This blocking peptide is recommended for use in combination with CXCR2 antibody, STJ500650
Post Translational Modifications Phosphorylated upon ligand binding.which is required for desensitization. (Microbial infection) Proteolytically cleaved by Staphylococcus aureus staphopain A/SspP. This cleavage inhibits CXCR2-dependent neutrophil activation and chemotaxis.
Function Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
Peptide Name C-X-C Chemokine Receptor Type 2
Cxc-R2
Cxcr-2
Cdw128b
Gro/Mgsa Receptor
High Affinity Interleukin-8 Receptor B
Il-8r B
Il-8 Receptor Type 2
Cd Antigen Cd182
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names C-X-C Chemokine Receptor Type 2 protein
Cxc-R2 protein
Cxcr-2 protein
Cdw128b protein
Gro/Mgsa Receptor protein
High Affinity Interleukin-8 Receptor B protein
Il-8r B protein
Il-8 Receptor Type 2 protein
Cd Antigen Cd182 protein
CXCR2 protein
IL8RB protein

Information sourced from Uniprot.org

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