CXCR2 Blocking Peptide for STJ500650 peptide (STJ503881)
SPECIFICATIONS
ImmunogenSynthetic peptide: EDLSNYSYSSTLPPFLLDAAPC Corresponding to amino acids 18-39 of Human CXCR2.
General Information
| Short Description | CXCR2 Blocking Peptide for STJ500650 is synthetically produced from the 18-39 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | CXCR2 |
| Gene ID | 3579 |
| Uniprot ID | CXCR2_HUMAN |
| Immunogen | Synthetic peptide: EDLSNYSYSSTLPPFLLDAAPC Corresponding to amino acids 18-39 of Human CXCR2. |
| Immunogen Region | 18-39 |
| Specificity | This blocking peptide is recommended for use in combination with CXCR2 antibody, STJ500650 |
Additional Info
| Post Translational Modifications | Phosphorylated upon ligand binding.which is required for desensitization. (Microbial infection) Proteolytically cleaved by Staphylococcus aureus staphopain A/SspP. This cleavage inhibits CXCR2-dependent neutrophil activation and chemotaxis. |
| Function | Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. |
| Peptide Name | C-X-C Chemokine Receptor Type 2Cxc-R2Cxcr-2Cdw128bGro/Mgsa ReceptorHigh Affinity Interleukin-8 Receptor BIl-8r BIl-8 Receptor Type 2Cd Antigen Cd182 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | C-X-C Chemokine Receptor Type 2 proteinCxc-R2 proteinCxcr-2 proteinCdw128b proteinGro/Mgsa Receptor proteinHigh Affinity Interleukin-8 Receptor B proteinIl-8r B proteinIl-8 Receptor Type 2 proteinCd Antigen Cd182 proteinCXCR2 proteinIL8RB protein |
Information sourced from Uniprot.org